February 27, 2014
Almost ten years ago, the group led by Erwin Wagner, currently at the Spanish National Cancer Research Centre (CNIO), developed genetically modified mice showing symptoms very reminiscent to psoriasis.
Now the group has discovered two possible novel treatments, based on existing pharmacological compounds, which are likely to cause fewer side effects.
It is known that in each patient there might be dozens of different mutated or altered genes, and therefore it is not an easy task to bring order to such a web of alterations and to identify which ones can trigger and are causal to disease development.
In the mouse model reported by this group in 2005, for example, psoriasis symptoms appeared when two genes were eliminated from the mouse's epidermis.
In the study led by Schönthaler, the first step was to compare skin affected by psoriasis patches with healthy skin from the same donor.
http://medx.cc/312726135
Almost ten years ago, the group led by Erwin Wagner, currently at the Spanish National Cancer Research Centre (CNIO), developed genetically modified mice showing symptoms very reminiscent to psoriasis.
Now the group has discovered two possible novel treatments, based on existing pharmacological compounds, which are likely to cause fewer side effects.
It is known that in each patient there might be dozens of different mutated or altered genes, and therefore it is not an easy task to bring order to such a web of alterations and to identify which ones can trigger and are causal to disease development.
In the mouse model reported by this group in 2005, for example, psoriasis symptoms appeared when two genes were eliminated from the mouse's epidermis.
In the study led by Schönthaler, the first step was to compare skin affected by psoriasis patches with healthy skin from the same donor.
http://medx.cc/312726135
